◉Swallow the tablets/capsule whole, do not crush or chew
Follow your doctor’s instructions for adjusting your dose.
Composition of Drug
◉This drug contain Amlodipine 5 mg+ Perindopril 4 mg.
How does the Drug work
◉Amlodipine and perindopril are two different medications that are often prescribed together to treat hypertension (high blood pressure). Let’s take a closer look at each medication and how they work individually and in combination:$$Amlodipine (5mg):
◉ Amlodipine is a calcium channel blocker. It works by inhibiting the entry of calcium ions into smooth muscle cells of blood vessels and the heart. Calcium plays a critical role in muscle contraction, including the muscles in the walls of blood vessels. By blocking calcium entry, amlodipine causes relaxation and dilation of the blood vessels, which leads to reduced peripheral resistance and lower blood pressure
The relaxation of blood vessels results in increased blood flow and improved oxygen delivery to tissues. Amlodipine’s action helps reduce the workload on the heart, making it more efficient in pumping blood throughout the body. This can lead to a decrease in blood pressure and a reduced risk of cardiovascular complications associated with hypertension
Perindopril (4mg):
◉ Perindopril belongs to a class of medications known as angiotensin-converting enzyme (ACE) inhibitors. ACE inhibitors work by inhibiting the activity of the angiotensin-converting enzyme, which is responsible for the conversion of angiotensin I to angiotensin II. Angiotensin II is a potent vasoconstrictor, meaning it narrows the blood vessels and raises blood pressure
By blocking the production of angiotensin II, perindopril causes blood vessels to dilate and relax, leading to decreased peripheral resistance and lower blood pressure. Additionally, ACE inhibitors can have other beneficial effects, such as reducing the workload on the heart and improving its pumping efficiency. They can also help protect the heart and kidneys from the damaging effects of high blood pressure over time
Combination Therapy (Amlodipine 5mg + Perindopril 4mg):
◉ The combination of amlodipine and perindopril is often prescribed for patients with hypertension who require more than one medication to achieve adequate blood pressure control. Combining amlodipine and perindopril allows for the complementary actions of both drugs, resulting in a more significant reduction in blood pressure compared to using either medication alone
Amlodipine and perindopril work through different mechanisms to relax blood vessels and reduce blood pressure. By combining these two drugs, the overall effect is greater than using either medication alone, and it can be more effective in managing hypertension, especially for patients with moderate to severe high blood pressure.
◉ It’s important to note that medication dosages and combinations can vary depending on individual patient factors and medical history. Always follow your healthcare provider’s instructions regarding the appropriate use and dosage of medications. If you have any concerns or questions about your medication, consult your doctor for personalized advice and guidance.
