◉Swallow the tablets/capsule whole, do not crush or chew

Follow your doctor’s instructions for adjusting your dose.

Composition of Drug
◉This drug contain Perindopril 8mg.
How does the Drug work
◉Perindopril is a medication used to treat high blood pressure (hypertension) and certain heart conditions. It is an angiotensin-converting enzyme (ACE) inhibitor, which means it works by blocking the action of the ACE enzyme in the body.

◉ Renin-angiotensin-aldosterone system (RAAS):The RAAS is a hormone system that plays a vital role in regulating blood pressure and fluid balance. It begins with the release of renin from the kidneys in response to low blood pressure or low sodium levels in the blood

Formation of Angiotensin II: Renin acts on a protein called angiotensinogen (produced by the liver) and converts it into angiotensin I. Angiotensin I is then converted into a much more potent and active hormone called angiotensin II by the ACE enzyme, which is primarily found in the lungs but can also be present in other tissues

Actions of Angiotensin II: Angiotensin II is a powerful vasoconstrictor, meaning it narrows blood vessels, leading to an increase in blood pressure. It also stimulates the release of another hormone called aldosterone from the adrenal glands, which promotes the reabsorption of sodium and water in the kidneys. This further contributes to increased blood volume and elevated blood pressure

Perindopril’s Mechanism of Action: Perindopril is an ACE inhibitor, and it works by blocking the ACE enzyme’s action. By doing so, Perindopril prevents the conversion of angiotensin I into angiotensin II. As a result, the levels of angiotensin II in the body are reduced

The key effects of Perindopril are as follows:

◉ a. Vasodilation: With reduced levels of angiotensin II, blood vessels can dilate or widen. This relaxation of blood vessels reduces resistance to blood flow, which leads to a decrease in blood pressure

b. Reduced Aldosterone Secretion: As a consequence of inhibiting angiotensin II, Perindopril also reduces the release of aldosterone. Lower levels of aldosterone decrease the reabsorption of sodium and water in the kidneys, further contributing to a reduction in blood volume and blood pressure

By inhibiting the RAAS, Perindopril helps lower blood pressure and ease the workload on the heart, making it an effective medication for hypertension and certain heart conditions.

◉ It’s important to note that Perindopril, like other antihypertensive medications, should be taken as prescribed by a healthcare professional, and patients should follow their doctor’s advice and monitoring for optimal results and safety. As with any medication, Perindopril may have side effects or interactions with other drugs, so it’s crucial to communicate openly with your healthcare provider about your medical history and current medications.